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In pediatric patients 2 to 5 years of age receiving Singulair, the following events occurred with a frequency ≥2% and more frequently than in pediatric patients who received placebo, regardless of causality assessment: fever, cough, abdominal pain, diarrhea, headache, rhinorrhea, sinusitis, otitis, influenza, rash, ear pain, gastroenteritis, eczema, urticaria, varicella, pneumonia, dermatitis, and conjunctivitis. In pediatric patients 6 to 14 years of age receiving Singulair, the following events occurred with a frequency ≥2% and more frequently than in pediatric patients who received placebo, regardless of causality assessment: pharyngitis, influenza, fever, sinusitis, nausea, diarrhea, dyspepsia, otitis, viral infection, and laryngitis. Singulair is used to treat the following conditions: Asthma, Asthma, Maintenance, Bronchospasm Prophylaxis, Chronic Obstructive Pulmonary Disease, Hay Fever. In these two studies, the following events were reported with Singulair with a frequency ≥1% and at an incidence greater than placebo, regardless of causality assessment: sinusitis, upper respiratory infection, sinus headache, cough, epistaxis, and increased ALT. It is especially important to check with your doctor before combining Singulair with phenobarbital or rifampin. Singulair administered once daily in the morning or in the evening was generally well tolerated with a safety profile similar to that of placebo.
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